This project took place at our Edinburgh centre which operated between 2008 and 2021.
This research study is now complete
Infection in the womb during pregnancy can harm the growing baby, and lead to premature labour. Often, these infections aren’t obvious. But, it’s vital to find them early so they can be treated before they do any harm, or the baby can be delivered if it is struggling.
Research taking place in Tommy’s Edinburgh Centre is looking at how ultrasound can be used to find inflammation and infection during pregnancy. So far, they have found that special ultrasound scans can detect when there is an infection in pregnant sheep. This works by picking up changes in the way the baby’s heart works when there is an infection present.
Clinical impact
Based on non-invasive ultrasound technology, this could allow for the timely diagnosis of the infection that causes a majority of extreme preterm birth. This test will be safe, rapid and allow for swift treatment to prevent preterm labour and injury to the developing baby.
Research papers
- Payne, M.S., et al., Intrauterine Candida albicans infection elicits severe inflammation in fetal sheep. Pediatric research, 2014.
- Stock et al, Spectral Tissue Doppler Imaging demonstrates cardiac dysfunction in response to intrauterine infection in fetal sheep. BJOG An International Journal of Obstetrics & Gynaecology 122:4-4 · April 2015
Timing
2014-2015
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